Magnetic Imaging & Other Biomedical Applications

Spin labels, when employing electron paramagnetic resonance (EPR), offer a highly sensitive imaging technology to elucidate structural information of large biomolecules. When appending to NIR dyes, spin hyperpolarization can be reached once NIR light penetrates through tissues and photoexcites the opto-spintronics, leading to far more enhanced signal-to-noise ratios for imaging. Moreover, spins can significantly accelerate the intersystem crossing (ISC) rates and consequently produce more triplet state NIR dyes in biological systems, which can be leveraged for improved biomedical applications, such as photodynamic therapy for cancer treatment and targeted drug delivery.